.Nature Medication, Posted online: 13 September 2024 doi:10.1038/ s41591-024-03261-7In the non-randomized stage 3b/4 DESTINY-Breast12 research study, trastuzumab deruxtecan (T-DXd) treatment of people along with HER2+ enhanced breast cancer cells as well as active or even stable human brain metastases presented consistent intracranial task as well as systemic effectiveness of T-DXd.