Medicine

Molecular classification to fine-tune operative and radiotherapeutic decision-making in meningioma

.MacFeeters Hamilton Neuro-Oncology Plan, Princess Margaret Cancer Cells Centre, College Wellness System and also College of Toronto, Toronto, Ontario, CanadaJustin Z. Wang, u00c2 Vikas Patil, u00c2 Alexander P. Landry, u00c2 Chloe Gui, u00c2 Andrew Ajisebutu, u00c2 Jeff Liu, u00c2 Rebeca Yakubov, u00c2 Ramneet Kaloti, u00c2 Farshad Nassiriu00c2 &amp u00c2 Gelareh ZadehDivision of Neurosurgery, Division of Surgical Treatment, College of Toronto, Toronto, Ontario, CanadaJustin Z. Wang, u00c2 Alexander P. Landry, u00c2 Chloe Gui, u00c2 Farshad Nassiriu00c2 &amp u00c2 Gelareh ZadehPrincess Margaret Cancer Cells Facility, University Wellness Network, Toronto, Ontario, CanadaJustin Z. Wang, u00c2 Vikas Patil, u00c2 Alexander P. Landry, u00c2 Chloe Gui, u00c2 Andrew Ajisebutu, u00c2 Jeff Liu, u00c2 Rebeca Yakubov, u00c2 Ramneet Kaloti, u00c2 Farshad Nassiriu00c2 &amp u00c2 Gelareh ZadehDalla Lana University of Public Health, University of Toronto, Toronto, Ontario, CanadaOlli SaarelaNRG Oncology Studies as well as Information Monitoring Center, Philadelphia, PA, USAStephanie L. Pughu00c2 &amp u00c2 Minhee WonTemerty School of Medicine, Educational Institution of Toronto, Toronto, Ontario, CanadaZeel PatelNeurosurgery Specialists of Tulsa, Tulsa, OK, USAChristopher WilsonDepartment of Neurological Surgical Treatment, Keck College of Medicine of the University of Southern California, Los Angeles, CA, USAAaron Cohen-GadolDepartment of Nerve Surgical Treatment, Indiana University Institution of Medicine, Indianapolis, IN, USAMohamed A. ZaazoueDepartment of Orthopedic Surgical Procedure, Washington Educational Institution College of Medication in St. Louis, St. Louis, MO, USAMohamed A. ZaazoueGerman Cancer Cells Consortium (DKTK), DKFZ Partner Internet Site Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyGhazaleh TabatabaiCluster of Superiority (EXC 2180) u00e2 $ Image Led as well as Functionally Instructed Cyst Therapiesu00e2 $, Eberhard Karls Educational Institution Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyGhazaleh TabatabaiDepartment of Neurology and also Interdisciplinary Neuro-Oncology, Center for Neuro-Oncology, Comprehensive Cancer Cells Center, Hertie Institute for Clinical Mind Investigation, Eberhard Karls College Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyGhazaleh Tabatabai, u00c2 Sylvia C. Kurzu00c2 &amp u00c2 Paul PasslackDepartment of Neurosurgery, Center for Neuro-Oncology, Comprehensive Cancer Center, Eberhard Karls Educational Institution Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyMarcos Tatagiba, u00c2 Felix Behling, u00c2 Mirjam Renovanz, u00c2 Jens Schittenhelmu00c2 &amp u00c2 Paul PasslackDepartment of Pathology, Educational Institution of San Francisco, San Francisco, CA, USADamian A. Almiron BonninHuman The Field Of Biology Division, Fred Hutchinson Cancer Cells Center, Seattle, WA, USAEric C. HollandDepartment of Person Oncology, University of Wisconsin Hospitals and also Clinics, Madison, WI, USATim J. KruserCentral Brain Growth Computer System Registry of the USA, Hinsdale, IL, USAJill S. Barnholtz-Sloanu00c2 &amp u00c2 Jill Barnholtz-SloanTrans Divisional Study Program (TDRP), Branch of Cancer Cells Public Health and also Genetic Makeup (DCEG), National Cancer Cells Principle, Bethesda, MD, USAJill S. Barnholtz-Sloanu00c2 &amp u00c2 Jill Barnholtz-SloanCenter for Biomedical Informatics &amp Infotech (CBIIT), National Cancer Principle, Bethesda, MD, USAJill S. Barnholtz-Sloanu00c2 &amp u00c2 Jill Barnholtz-SloanPiedmont Brain Tumor Center, Piedmonth Healthcare Unit, Atlanta Georgia, GA, USAAndrew E. Sloanu00c2 &amp u00c2 Andrew E. SloanDepartment of Pathology, Northwestern University, Evanston, IL, USACraig Horbinskiu00c2 &amp u00c2 Craig M. HorbinskiLou &amp Jean Malnati Mind Tumor Institute at the Lurie Comprehensive Cancer Cells Facility, Northwestern College, Evanston, IL, USACraig Horbinskiu00c2 &amp u00c2 Craig M. HorbinskiDepartment of Neurosurgery, Vanderbilt Educational Institution Medical Facility, Nashville, TN, USASilky Chotaiu00c2 &amp u00c2 Lola B. ChamblessDepartment of Laboratory Medication and also Pathobiology, University of Toronto, Toronto, Ontario, CanadaAndrew GaoDivision of Neurosurgery, University of British Columbia, Vancouver, British Columbia, CanadaAlexander D. Rebchuku00c2 &amp u00c2 Serge MakarenkoDepartment of Pathology &amp Research Laboratory Medicine, Professors of Medicine, Educational Institution of British Columbia, Vancouver, British Columbia, CanadaStephen YipDepartment of Neuropathology, Principle of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, GermanyFelix Sahm, u00c2 Felix Sahmu00c2 &amp u00c2 Andreas von DeimlingClinical Collaboration Unit Neuropathology, German Cancer (DKFZ), Heidelberg, GermanyFelix SahmDepartment of Pathology, Leiden University Medical Facility, Leiden, The NetherlandsSybren L. N. MaasDepartment of Pathology, Erasmus MC Cancer Cells Principle, Educational Institution Medical Facility Rotterdam, Rotterdam, The NetherlandsSybren L. N. MaasRadiation Medicine System, Little Princess Margaret Cancer Facility, Toronto, Ontario, CanadaDerek S. TsangRadiation Oncology, Utah Cancer Specialists, Salt Pond City, UT, USAC. Leland RogersCenter for Cancer Analysis, National Cancer Cells Principle, Bethesda, MD, USAKenneth AldapeMiami Neuroscience Principle, Baptist Wellness, Miami, FL, USAMichael W. McDermottDepartment of Neurosurgery, Addenbrookeu00e2 $ s Healthcare facility, Cambridge, UKThomas Santariusu00c2 &amp u00c2 Daniel M. FountainDepartment of Neurosurgery, University Hospitals Cleveland as well as Instance Western Get College, Cleveland, OH, USAWarren SelmanDepartment of Pathology, Educational Institution Hospitals Situation Medical Facility, Cleveland, OH, USAMarta CouceDepartment of Neurosurgery, Centro Hospitalar Universitu00c3 u00a1 rio S. Jou00c3 u20a4 o, Porto, PortugalBruno CarvalhoCenter for Neuro-Oncology, Dana-Farber/Brigham as well as Womenu00e2 $ s Cancer cells Facility, Boston, MA, USAPatrick Y. WenDepartment of Neurosurgery, Duke Educational Institution, Durham, NC, USAKyle M. WalshDepartment of Neurosurgery, Erasmus MC Cancer Principle, Erasmus Educational Institution Medical Facility, Rotterdam, The NetherlandsEelke M. BosDepartment of Neurosurgery, Brigham as well as Womenu00e2 $ s Health center, Harvard Medical University, Boston, MA, USAWenya Linda BiDepartment of Radiology, Brigham and Womenu00e2 $ s Medical facility, Dana-Farber Cancer Cells Institute, Harvard Medical College, Boston, MA, USARaymond Y. HuangDepartment of Neurology, Branch of Neuro-Oncology, Massachusetts General Healthcare Facility, Harvard Medical School, Boston Ma, MA, USAPriscilla K. BrastianosDepartment of Radiation Oncology, Massachusetts General Healthcare Facility, Boston, MA, USAHelen A. ShihDepartment of Neurology, Hermelin Brain Tumor Facility, Holly Ford Wellness, Detroit, MI, USATobias WalbertDepartment of Neurosurger, Hermelin Brain Cyst Facility, Henry Ford Wellness, Detroit, MI, USAIan Lee, u00c2 Ana Valeria Castro, u00c2 Houtan Noushmehru00c2 &amp u00c2 James M. SnyderDepartment of Pathology, University of Texas Medical Division, Galveston, TX, USAMichelle M. FelicellaDepartment of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, ItalyFrancesco Dimecou00c2 &amp u00c2 Andrea SaladinoNeuropathology System, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, ItalyBianca PolloDepartment of Neurosurgery, LMU University Hospital, LMU Munich, Munich, GermanyChristian Schichoru00c2 &amp u00c2 Ju00c3 u00b6 rg-Christian TonnDepartment of Radiation Oncology, Charitu00c3 u00a9 u00e2 $ "Universitu00c3 $ tsmedizin Berlin, Corporate Member of Freie Universitu00c3 $ t Berlin and also Humboldt-Universitu00c3 $ t zu Berlin, Berlin, GermanyFelix EhretDepartment of Radiology, Mayo Medical Clinic, Rochester, MN, USATimothy J. KaufmannDepartment of Research Laboratory Medication as well as Pathology, Mayonnaise Clinic, Rochester, MN, USADaniel H. Lachance, u00c2 Caterina Gianniniu00c2 &amp u00c2 Aditya RaghunathanDepartment of Oncology, Division of Medical Oncology, Mayonnaise Clinic, Rochester, MN, USAEvanthia GalanisDepartments of Neuro-Oncology and also Neurosurgery, Moffitt Cancer Cells Facility, Tampa Florida, FL, USAMichael A. VogelbaumNeuropathology System, Surgical Neurology Division, National Institute of Nerve Conditions and Movement, National Institutes of Wellness, Bethesda, MD, USAPatrick J. CiminoDepartment of Nerve Surgical Operation, Northwestern College, Northwestern Medication, Chicago, IL, USAMark YoungbloodDepartment of Pathology, NYU Langone Medical Facility, New York, NY, USAMatija SnuderlDepartment of Radiation Oncology, NYU Langone Wellness, The Big Apple College, New York, NY, USAErik P. SulmanDepartment of Neurosurgery, Educational Institution of Oklahoma Health And Wellness Sciences Facility, Oklahoma Metropolitan Area, OK, USAIan F. DunnPeninsula Schools of Medication as well as Dental Care, Plymouth University, Plymouth, UKC. Oliver HanemannDepartment of Neurosurgery, Royal University of Surgeons in Ireland, Dublin, IrelandMohsen JavadpourDepartment of Anatomical and Cell Pathology, Chinese College of Hong Kong, Shatin, Hong KongHo-Keung NgDepartment of Human Genetic Makeup, Educational Institution of California, Los Angeles, Los Angeles, CA, USAPaul C. BoutrosDepartment of Neurosurgery, University of California, Los Angeles, Los Angeles, USARichard G. EversonDepartment of Neurosurgery, University Hospital of Larissa, Institution of Medication, Educational Institution of Thessaly, Larissa, GreeceAlkiviadis Tzannisu00c2 &amp u00c2 Konstantinos N. FountasDepartment of Neurosurgery, Educational Institution Medical Center Regensburg, Regensburg, GermanyNils Ole SchmidtDepartment of Surgery, Department of Neurosurgery, University of Alberta, Edmonton, Alberta, CanadaKarolyn AuCenter of Neurosurgery, Division of General Neurosurgery, College of Fragrance, Cologne, GermanyRoland GoldbrunnerDepartment of Neurology, Personnel of Medicine, Teaching Hospital Perfume, Educational Institution of Perfume, Cologne, GermanyNorbert GalldiksLaboratory for Neurooncology and Speculative Neurosurgery, Team of General Neurosurgery, Facility for Neurosurgery, Cologne, GermanyMarco TimmerDepartment of Neurosurgery, University Hospital of Copenhagen-Rigshospitalet, Copenhagen, DenmarkTiit Illimar MathiesenDepartment of Neurosurgery, College Medical Facility Hamburg-Eppendorf, Hamburg, GermanyManfred Westphal, u00c2 Katrin Lamszusu00c2 &amp u00c2 Franz L. RicklefsDepartment of Neurosurgery, Teaching Hospital Heidelberg, Heidelberg, GermanyChristel Herold-Mende, u00c2 Christine Jungku00c2 &amp u00c2 Gerhard JungwirthDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, GermanyMaximilian DengLeeds Principle of Medical Research at St. Jamesu00e2 $ s, Educational institution of Leeds, Leeds, UKSusan C. ShortDepartment of Neurosurgery, The Walton Center NHS Base Leave, Liverpool, UKMichael D. JenkinsonInstitute of Neuropathology, Otto-Von-Guericke-University, Magdeburg, GermanyChristian MawrinDepartment of Neurosurgery, Manchester Centre for Scientific Neurosciences, Salford Royal Healthcare Facility NHS Foundation Trust Fund, Salford, UKAbdurrahman I. Islimu00c2 &amp u00c2 Omar N. PathmanabanDepartment of Neurosurgery, Royal Melbourne Health Center, Melbourne, VIC, AustraliaKatharine J. Drummondu00c2 &amp u00c2 Andrew MorokoffDepartment of Radiation Oncology, University of The Golden State, San Francisco, San Francisco, CA, USADavid R. RaleighDepartment of Neurosurgery, College of California, San Francisco, San Francisco, CA, USADavid R. Raleighu00c2 &amp u00c2 Nicholas A. ButowskiDepartment of Pathology, Educational Institution of California, San Francisco, San Francisco, CA, USADavid R. Raleighu00c2 &amp u00c2 Arie PerrySchool of Pharmaceutical Sciences of Ribeiru00c3 u20a4 o, Preto University of Su00c3 u20a4 o Paulo, Su00c3 u20a4 o Paulo, BrazilTathiane M. MaltaDepartment of Pathology and Lab Medication, Educational Institution of Saskatchewan University of Medicine, Saskatoon, Saskatchewan, CanadaViktor ZherebitskiyDivision of Neurosurgery, Royal University Hospital, College of Saskatchewan, Saskatoon, Saskatchewan, CanadaLuke HnennyUSC Pituitary Center, USC Radiosurgery Center, Keck College of Medicine of USC, Los Angeles, CA, USAGabriel ZadaDepartment of Neurosurgery, St. Barbara-Klinik Hamm-Heessen, Hamm, GermanyAntonio SantacroceNuclear Medication and Medical Molecular Imaging, Team of Radiology, Eberhard Karls College of Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyChristian Los Angeles Fougu00c3 u00a8 reDepartment of Neurosurgery, Yale University of Medicine, New Place, CT, USAJennifer MoliternoDepartment of Neurosurgery, Tufts Medical Center, Boston, MA, USAAlper DincerArthur and Sonia Labatt Brain Tumour Study Centre, The Healthcare Facility for Sick Kid, Toronto, Ontario, CanadaGelareh ZadehManuscript writing, figure preparation, general analytical analysis and also standard bioinformatics were carried out by J.Z.W. Molecular classification, style building and bioinformatics assist was actually offered through V.P., A.P.L. and J.L. TERT promoter sequencing was conducted through C.G. Copy number variant analysis and referring to as were actually carried out by A.P.L. Molecular analyte removal, quantification and also sequencing were actually performed by J.Z.W., A.P.L., C.G., A.A. and also Z.P. DKFZ methylation training class as well as subclass resolution was actually performed through R.Y. and also R.K. making use of the openly readily available online resource generated by F.S. RNA sequencing analysis was actually conducted through V.P. as well as J.L. Biostatistical evaluation was actually carried out by O.S. Medical information coming from the NRG Oncology RTOG-0539 meningioma situations were supplied by S.L.P. and also M.W. Clinical meningioma examples and also matching clinical data were actually provided by C.W., A.C.G., M.A.Z., G.T., M.T., F.B., D.A.A.B., E.C.H., J.B.S., A.E.S., C.H., S.C., L.B.C., A.R., S.M. and also S.Y. Pathologic customer review was carried out by A.G. and also K.A. Radiotherapy data of institutional retrospective meningioma scenarios were offered through D.S.T. Research study design and interpretation were actually performed by J.Z.W, F.N. as well as G.Z. All of writers took part in document customer review and corrections in some ability.

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